Is it permissible to deal or work with Microsoft, which openly supports Zionism, especially for those specialized in programming?

The default rule is permissibility in dealing with non-Muslims and their companies, provided that the Muslim does not directly engage in or assist in any prohibited act. Indeed, the Prophet, peace and blessings be upon him, and his companions and the righteous predecessors dealt with Jews and Christians. However, dealing with companies that scholars have deemed subject to boycott due to their aggression against Muslims and their holy sites is prohibited. Therefore, there is no objection to dealing with or working for the aforementioned company, as long as you do not directly engage in or assist in any prohibited act therein, or if it is not one of the boycotted companies.