Which is more deserving of a sister's zakat, given that her wealth has reached the nisab and a full year has passed over it for several years, and she does not pay it under the pretext of not having liquidity: should she give it to her poor husband for him to spend on the family, or to her only unmarried brother to help him achieve self-sufficiency, or to orphan girls?

You must withdraw the deposit from the usurious bank and offer sincere repentance, disposing of the usurious interest by spending it on general Muslim welfare. The original capital is what is subject to zakat (definition) if it reaches the nisab (definition), and zakat for past years must be given to those entitled to it as mentioned in the verse from Surat At-Tawbah (definition). It is recommended to give zakat to poor relatives who are not dependents, such as a poor unmarried brother, and a husband if he is eligible for zakat. It is permissible to give zakat to those in need of essential marriage expenses.