Does the third divorce take effect with the words "You are divorced" during intense anger, knowing that it is the third divorce and the marital dispute has been ongoing for years?

The divorce is valid, and since this is the third pronouncement, the wife is unlawful to him and she does not become lawful for him again unless she marries another man a valid marriage and he then divorces her after consummation. Care must be taken to avoid the causes of anger.