Is it obligatory to make up the prayers that I was negligent in performing and abandoned, knowing that performing prayer increases distress and hardship?

A Muslim woman must continue to strive against her soul and abandon whispers (waswas) by continuing treatment and Ruqyah (definition) Shariah. Prayer is not a cause of distress, but rather one of the means of healing. She must perform prayers on time, seek God's forgiveness for missed prayers, and make them up in a way that does not harm her, for God's debt is most worthy of being paid.