Is it permissible for men and women to hold hands during Tawaf, forming a circle around the women, which might lead to circumambulating with one's back to the Kaaba or having the Kaaba on one's right side?

This act is dangerous and harmful, for it harms people by their gathering, and it is dangerous because circumambulation (tawaf) is not valid if you place the Kaaba behind your back or in front of your face. The Kaaba must be to your left during circumambulation.