What is the way to repent and lift Allah’s wrath for someone who has committed many sins and is suffering their consequences, and is facing difficulty in maintaining regular prayer due to successive calamities?

You will not taste happiness and comfort except by repenting to Allah from destructive sins, especially abandoning prayer. A good life is only achieved through obedience to Allah. Calamities befall a servant due to their negligence and disobedience. The duty upon the onset of a calamity is to hold oneself accountable and make sincere repentance from all transgressions, maintain prayers, and perform acts of obedience. The door of repentance is open for whoever repents sincerely, for Allah accepts the repentance of the repentant and overlooks their lapses. Therefore, repent, supplicate to Allah, seek forgiveness, accompany righteous people, and strive against yourself and your devil.