What is the ruling of Islamic law on a female with a male body and mindset transitioning to a male, given that attempts at hormonal therapy have been unsuccessful and have led to her desire to commit suicide?

Suicide is not a solution to any problem; rather, it is a calamity and one of the gravest sins. This world is wider and happier than the girl might imagine, and it is a path to eternal happiness through righteous deeds.

What the girl feels as the "imprisonment of femininity" is merely an illusion, for a person is questioned about their righteous deeds, not about their gender identity. One must not despair of specialized medical treatment, and if treatment is not possible, one should live with the problem with patience and contentment, bearing in mind that every person is tested.