What is the religious ruling on a wife refusing intimacy with her husband because of his drunkenness, and is she considered cursed for refusing his request, and what can she do to keep him away from these sins?

Alcohol is one of the gravest major sins, and its addict must repent from it. You must advise your husband to abandon it gently and kindly, and obey him in what is good, especially in the marital bed, because there is no sin upon you for his disobedience, as Allah Almighty says: (And no bearer of burdens will bear the burden of another). You can seek the help of his friends and relatives to advise him.