What is the ruling on Iʿtikāf at home between the Asr prayer and the Maghrib Adhan, and is it permissible to cut ties with relatives if a person is certain of harm?

For the validity of I'tikaf (spiritual retreat), it is a condition that it takes place in a mosque for both men and women. The correct view is that I'tikaf is not valid in a prayer room at home for men or women, based on the Almighty's saying: "while you are secluded in the mosques." As for closing the mosque outside prayer times, the default is against it unless there is a recognized benefit. It is permissible to seclude oneself from family for self-reflection and accountability, or for reading, seeking knowledge, and remembering Allah. Similarly, if mixing with them would lead to harm or wrongdoing, and your presence would not be a cause for its removal or change, then seclusion is permissible.