Is entering a Sharia specialization against the parents' refusal considered an act of disobedience (ʿuqūq), given the fear of abandoning religious commitment or forgetting the purpose of creation if this specialization is not pursued?

Calling to Allah is one of the greatest obligations and noblest deeds. Studying medicine is beneficial if the student has the right intention, especially for Muslim women, to safeguard the modesty of women. There is no objection to combining the study of medicine and calling to Allah, but dedicating oneself entirely to calling to Allah is more complete. If you predominantly believe that studying medicine will distract you from calling to Allah and seeking sacred knowledge, then there is no blame upon you for transferring to a college of Islamic studies. This would not be considered disobedience if you gently apologize to your parents. However, you must turn away from studying medicine if it will lead you to what Allah has forbidden.