Is the reason for difficulties in affairs resigning from a previous job despite performing Istikhara?

The nature of this worldly life is a fluctuation between hardship and ease, and between adversity and prosperity. You must have a good opinion of Allah Almighty, for relief comes with distress, and with hardship comes ease. Do not despair of Allah's kindness, mercy, and imminent facilitation. Take recourse to the means, such as supplication, repentance, and reliance upon Allah. Continue searching for suitable work, confident in Allah's grace and mercy, and you will attain your goal.