Is it obligatory to return the honey to the first woman who gifted it, or to inform her of the patient's refusal to accept it?

A gift is not owned until it is taken possession of. Therefore, the donee's disposal of it before taking possession is not valid, and it remains the property of the donor. Hence, the questioner must return the honey to its donor if the donee did not take possession of it, or seek the donor's permission to dispose of it or take it. As for the discomfort of returning a gift, it can be addressed by explaining the details.