Is it permissible for a grandfather to disinherit his daughter and give her share to his granddaughter-in-law, especially since she did not pay the remainder of her granddaughter-in-law's dowry, mistreated her, and abandoned her father for over 22 years?

The woman's mahr (dowry) is an obligatory right due to her from her husband. The questioner's aunt has no right to demand the remaining portion of her mahr other than her husband. The aunt must not be an obstacle between her son and the fulfillment of his obligations. She must honor her father and treat him kindly, and seek out someone who can help reconcile her with her father. Whatever her father gifted to the questioner, if he was sound of mind when he disposed of it and she took possession of it, then that gift is valid. As for any wealth the father left behind after his death, the daughter has her rightful share of the inheritance, and no one is permitted to withhold it from her.