What is the ruling on disposing of a house owned by a company, knowing that the company exploiting it will sell alcohol therein, and is it sufficient to separate the profits derived from selling alcohol from others to avoid the unlawful?

As long as the company intends to use the house for selling alcoholic beverages, it is impermissible to rent it to them, as this constitutes cooperation in sin. Means have the same rulings as their ends, and whatever leads to the forbidden is itself forbidden. Jurists have explicitly stated the prohibition of selling grapes to someone who will use them to make wine, and renting a house to someone who will use it for forbidden purposes, as this constitutes aiding in what Allah has prohibited. It is narrated that Sa'd ibn Abi Waqqas ordered the uprooting of grapevines that were only suitable for making wine. Ibn Qudamah stated that everything intended for a forbidden purpose, such as renting a house for selling alcoholic beverages, is forbidden and the the contract is void. Merely separating the percentage of alcohol income from the rental amount does not make the rest permissible; the entire rental amount is forbidden. The rental amount must be known and specified; it is not permissible to make it a percentage of profit.