Were injections known during the time of the Prophet Muhammad, peace be upon him, what types of them existed then, and what is the ruling on taking them in Ramadan, with a request for detailed answers from the Quran and Sunnah?

"Instillation is the pouring or inserting of medicine into the anus. It is permissible to use it for medical treatment if there is a need and if the substance is lawful. However, it is disliked if there is no need, due to its resemblance to the act of the people of Lot. The majority of jurists hold that it invalidates fasting in Ramadan."