What is the ruling on using bear bile?

The question is unclear, but if it pertains to the ruling on using a female bear, there is no difference in the ruling between male and female animals. It is permissible for a Muslim to tame and use animals for their benefit, as long as it is not forbidden, because the default for things and benefits is permissibility unless there is evidence of prohibition, based on His (Allah's) saying: "It is He who created for you all of that which is on the earth."