Is there a relationship between sins and their effect on a person's psyche and his relationships with others, based on feelings of worry, thinking about the unknown, anxiety about the future, and a sense of worthlessness?

What you feel of anxiety, sorrow, and people not valuing you might be due to sins and transgressions, as they are a strong cause for the misfortunes and chest tightness that afflict a person. Allah Almighty says: "And whatever strikes you of disaster - it is because of what your hands have earned; and He pardons much," and He says: "But whoever turns away from My remembrance - indeed, he will have a constricted life."

Life disconnected from Allah is constricted, no matter how expansive it seems. Therefore, you should repent and regret what you have neglected, resolve to adhere to Allah's religion, and seek righteous companionship that will assist you. Remember death, the grave, and the reckoning. Treat worldly anxiety with the narrated supplications, such as: "O Allah, I am Your servant, son of Your servant, my forelock is in Your hand...", and "O Allah, I seek refuge in You from anxiety and sorrow...".