Is the sacrifice valid if one is in a state of major ritual impurity (janābah), or is it not valid?

The question is unclear. However, if it revolves around the validity of the sacrifice performed by someone who is in a state of janabah (major ritual impurity), then the answer is yes. The sacrifice performed by someone in a state of janabah is valid because ritual purity from janabah is not one of the conditions for the validity of the sacrifice.