What is the advice for a young man who feels anxiety and sorrow and has lost his sense of intimacy despite his consistent prayer and his previous memorization of the Quran, and who feels estranged among people?

One must thank Allah for the blessing of memorizing the Quran by committing to it and not forgetting it. Neglecting to preserve it is a sin that may amount to major sins. The desolation the questioner feels might be due to abandoning the Quran. Therefore, it is advised to commit to the Quran and repent to Allah to attain solace and tranquility.