Is it possible to become exhausted by a spiritual illness without feeling or tasting Zamzam water, despite being affected by Ruqyah Shar'iyah?

You can consult specialists in medical matters regarding fatigue from illness. Zamzam water is one of the most beneficial remedies, and it can be drunk for all needs, as the Prophet, peace and blessings be upon him, said: "Zamzam water is for what it is drunk for" and "Zamzam is a delicious food and a cure for illness." Ibn al-Qayyim mentioned that he benefited from it in curing an ailment he suffered, and Ibn Qudamah stated that it is recommended to drink from it and fill oneself with it with the intention of healing, as Ibn Abbas used to direct.